2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Hippo (MST)
  5. Hippo (MST) Modulator

Hippo (MST) Modulator

Hippo (MST) Isoform Comparison

Hippo (MST) Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-400902
    VT3989
    		Modulator 99.61%
    VT3989 is an orally active pan-TEAD autopalmitoylation inhibitor that modulates the Hippo signaling pathway. VT3989 directly binds to TEAD transcription factors to block their palmitoylation modification, thereby disrupting the formation of YAP/TAZ-TEAD complexes and inhibiting downstream oncogenic transcriptional activity. VT3989 effectively inhibits the growth of NF2-deficient schwannoma and meningioma cells and reverses the Schwann cell phenotype. In addition, VT3989 exerts a synergistic effect when combined with Osimtinib (HY-15772) in EGFR-mutant non-small cell lung cancer models, significantly delaying tumor recurrence and prolonging survival. VT3989 can be used for the research of epithelioid hemangioendothelioma, malignant pleural mesothelioma, type 2 neurofibromatosis and related advanced solid tumors.